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The pathology, in vitro growth pattern and karyotype of an Ewing's sarcoma are ght and electron microscopic findings of a talus biopsy showed pathologic characteristics typical of Ewing's vitro tumor cells grew on a monolayer as small, plump, refractile cells. Tumor cells were also capable of proliferating in soft agar.
Most cases of Ewing sarcoma (about 85%) are the result of a defining genetic event; a reciprocal translocation between chromosomes 11 and 22, t(11,22), which fuses the Ewing's Sarcoma Breakpoint Region 1 gene of chromosome 22 (which encodes the EWS protein) to the Friend Leukemia Virus Integration 1 gene (which encodes Friend Leukemia Integration 1 transcription factor (FLI1), a member of the ETS transcription factor family) of chromosome 11.
Ewing sarcoma belongs to the group of neoplasms commonly referred to as small, round, blue-cell tumors of e individual cells of Ewing sarcoma contain round-to-oval nuclei, with fine dispersed chromatin without nucleoli.
Characterization of the A673 cell line (Ewing tumor) by molecular cytogenetic e A673 cell line was established from a patient with a primary rhabdomyosarcoma (RMS), which is referred to in the literature either as a Ewing tumor (ET) or as though the two tumoral types are associated with specific and well-characterized translocations, no cytogenetic report on this cel ….
The Ewing sarcoma family of tumors includes osseous Ewing sarcoma, extraskeletal Ewing sarcoma, primitive neuroectodermal tumor, and Askin ey share a karyotype abnormality with translocation involving chromosomes 11 and 22. Histologically, these lesions demonstrate crowded sheets of small round blue cells.
Roberts P, Burchill SA, Brownhill S, et al.: Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing's sarcoma family of tumors: a study by the United Kingdom Cancer Cytogenetics and the Children's Cancer and Leukaemia Group.